Exploring Constructions of the Meanings of Play among Korean Preservice Kindergarten Teachers

The purpose of this study was to explore what the word "play" means and implies for Korean preservice kindergarten teachers in an early childhood teacher education program. The research questions under investigation were: (1) How do Korean preservice teachers with an early childhood emphasis view play? (2) How do factors such as culture and education influence the constructing of these views? The participants were ten Korean preservice kindergarten teachers enrolled in the Department of Early Childhood Education in one teacher education college in Korea. The data for this study was collected through in-depth qualitative interviews both individual and group and other qualitative methods. The findings of this study showed that Korean preservice kindergarten teachers had a conceptual conflict in the perception of general play and educational play. General play was considered as a fun, enjoyable, and spontaneous activity that is engaged in without concern for a specific outcome. General play was also thought as the opposite concept to work or study. Educational play was regarded as an ironical concept, since Korean preservice kindergarten teachers thought that learning occurs through working, not playing. Korean preservice kindergarten teachers theoretically advocated for the pedagogy of learning through play, just as they were taught in the teacher education program. However, Korean preservice kindergarten teachers did not agree with the practical effect of play on children's learning. Korean preservice kindergarten teachers were more supportive of a structured and pre-planned program for young children, believing that it resulted in better learning opportunities for children than a play-oriented program. The findings of the study revealed that personal experiences with play, the kind of education of the preservice teachers themselves received in their teacher training program, and Korean culture had significant roles in influencing the participant preservice teachers' ideas on play. This study implies that interpretations of play as an educational tool vary from culture to culture. Further research is needed to more deeply understand how views and attitudes on play are created and enacted

Unrecognized Dural Tear During Transforaminal Percutaneous Endoscopic Lumbar Discectomy

As transforaminal percutaneous endoscopic lumbar discectomy (PELD) becomes more aggressively implemented, the risk for dural tears may increase and lead to severe neurological sequelae. Diagnostic and management strategies for these situations, however, have not been established. This report describes an unrecognized dural tear during transforaminal PELD. A 38‐year‐old woman sustained an unrecognized dural tear during transforaminal PELD at the L4‐5 level. Postoperative radicular symptoms were initially misdiagnosed as recurrent lumbar disc herniation. Despite revision PELD, symptoms were not resolved. The patient underwent endoscopic exploration at the authors’ clinic to examine the cause of radicular pain, which revealed a small dural tear and nerve root entrapment at the lateral aspect of the dura. Open repair using interbody fusion was performed at the L4‐5 level. The dural tear was primarily closed and the pinched nerve root was relieved. The patient’s pain symptoms improved, and she was discharged after adequate wound care. Although PELD is an effective and safe minimally invasive technique, incidental dural tears can occur. Surgeons should be aware of the risks for dural damage and have comprehensive knowledge of clinical features. Early diagnosis with a high level of suspicion is essential to preventing long‐term neurological sequelae

Investigation of the SH3BP2 Gene Mutation in Cherubism

Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients. In this study, we examined a 6-year-old Korean boy and his family. We found a Pro418Arg mutation in the SH3BP2 gene of the patient and his mother. A father and his 30-month-old younger brother had no mutations. Immunohistochemically, the multinucleated giant cells proved positive for CD68 and tartrate-resistant acid phosphatase (TRAP). Numerous spindle-shaped stromal cells expressed a ligand for receptor activator of nuclear factor kB (RANKL), but not in multinucleated giant cells. These results provide evidence that RANKL plays a critical role in the differentiation of osteoclast precursor cells to multinucleated giant cells in cherubism. Additionally, genetic analysis may be a useful method for differentiation of cherubism.</p

Printing of wirelessly rechargeable solid-state supercapacitors for soft, smart contact lenses with continuous operations

Recent advances in smart contact lenses are essential to the realization of medical applications and vision imaging for augmented reality through wireless communication systems. However, previous research on smart contact lenses has been driven by a wired system or wireless power transfer with temporal and spatial restrictions, which can limit their continuous use and require energy storage devices. Also, the rigidity, heat, and large sizes of conventional batteries are not suitable for the soft, smart contact lens. Here, we describe a human pilot trial of a soft, smart contact lens with a wirelessly rechargeable, solid-state supercapacitor for continuous operation. After printing the supercapacitor, all device components (antenna, rectifier, and light-emitting diode) are fully integrated with stretchable structures for this soft lens without obstructing vision. The good reliability against thermal and electromagnetic radiations and the results of the in vivo tests provide the substantial promise of future smart contact lenses

The Role of Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in the Myogenic Tone of Posterior Cerebral Arteries

AIMS: The goal of the current study was to determine whether the sphingosine kinase 1 (SK1)/sphingosine-1-phosphate (S1P) pathway is involved in myogenic vasoconstriction under normal physiological conditions. In the present study, we assessed whether endogenous S1P generated by pressure participates in myogenic vasoconstriction and which signaling pathways are involved in SK1/S1P-induced myogenic response under normal physiological conditions. METHODS AND RESULTS: We measured pressure-induced myogenic response, Ca(2+) concentration, and 20 kDa myosin light chain phosphorylation (MLC(20)) in rabbit posterior cerebral arteries (PCAs). SK1 was expressed and activated by elevated transmural pressure in rabbit PCAs. Translocation of SK1 by pressure elevation was blocked in the absence of external Ca(2+) and in the presence of mechanosensitive ion channel and voltage-sensitive Ca(2+) channel blockers. Pressure-induced myogenic tone was inhibited in rabbit PCAs treated with sphingosine kinase inhibitor (SKI), but was augmented by treatment with NaF, which is an inhibitor of sphingosine-1-phosphate phosphohydrolase. Exogenous S1P further augmented pressure-induced myogenic responses. Pressure induced an increase in Ca(2+) concentration leading to the development of myogenic tone, which was inhibited by SKI. Exogenous S1P further increased the pressure-induced increased Ca(2+) concentration and myogenic tone, but SKI had no effect. Pressure- and exogenous S1P-induced myogenic tone was inhibited by pre-treatment with the Rho kinase inhibitor and NADPH oxidase inhibitors. Pressure- and exogenous S1P-induced myogenic tone were inhibited by pre-treatment with S1P receptor blockers, W146 (S1P1), JTE013 (S1P2), and CAY10444 (S1P3). MLC(20) phosphorylation was increased when the transmural pressure was raised from 40 to 80 mmHg and exogenous S1P further increased MLC(20) phosphorylation. The pressure-induced increase of MLC(20) phosphorylation was inhibited by pre-treatment of arteries with SKI. CONCLUSIONS: Our results suggest that the SK1/S1P pathway may play an important role in pressure-induced myogenic responses in rabbit PCAs under normal physiological conditions

Optimal Design of a Centrifugal Compressor Impeller Using Evolutionary Algorithms

An optimization study was conducted on a centrifugal compressor. Eight design variables were chosen from the control points for the Bezier curves which widely influenced the geometric variation; four design variables were selected to optimize the flow passage between the hub and the shroud, and other four design variables were used to improve the performance of the impeller blade. As an optimization algorithm, an artificial neural network (ANN) was adopted. Initially, the design of experiments was applied to set up the initial data space of the ANN, which was improved during the optimization process using a genetic algorithm. If a result of the ANN reached a higher level, that result was re-calculated by computational fluid dynamics (CFD) and was applied to develop a new ANN. The prediction difference between the ANN and CFD was consequently less than 1% after the 6th generation. Using this optimization technique, the computational time for the optimization was greatly reduced and the accuracy of the optimization algorithm was increased. The efficiency was improved by 1.4% without losing the pressure ratio, and Pareto-optimal solutions of the efficiency versus the pressure ratio were obtained through the 21st generation

Immune-inflammation gene signatures in endometriosis patients

To determine if the molecular profiles of endometriotic lesions contain informative measures of inflammation and immune dysfunction that may contribute to better understanding of the interplay between immune dysfunction and inflammation and their contribution to endometriosis pathogenesis

Primary malignant melanoma of the vagina in a postmenopausal woman

Primary malignant melanoma of the vagina, a very rare malignancy, is very aggressive and highly metastatic. Primary vaginal melanoma usually has a poor clinical prognosis, because it is often diagnosed at an advanced stage. We present a case of an 80-year-old postmenopausal woman with pigmented lesion of the vagina. The histopathology of the lesion revealed malignant melanoma. The patient was treated surgically, with wide local excision of the vaginal lesion. Left inguinal lymphadenectomy, based on the positron emission tomography-computed tomography (PET-CT) images, found metastatic melanoma. We present a case report of postmenopausal woman with primary vaginal melanoma